Effects and Mechanisms of Exercise on Brain-Derived Neurotrophic Factor (BDNF) Levels and Clinical Outcomes in People with Parkinson's Disease: A Systematic Review and Meta-Analysis.

Daan G M KaagmanErwin Everardus Henri van WegenNatalie CignettiEmily RothermelTim VanbellingenMark A Hirsch

Published in: Brain sciences (2024)

Key results of this systematic review are that exercise therapy is effective in raising serum BDNF levels and seems effective in alleviating PD motor symptoms. Exercise therapy confers neuroplastic effects on Parkinson brain, mediated, in part, by BDNF.

Keyphrases

high intensity
systematic review
physical activity
resistance training
stress induced
meta analyses
randomized controlled trial
multiple sclerosis
cell therapy
depressive symptoms
mesenchymal stem cells
blood brain barrier
sleep quality