External Validation of a Prognostic Model of Overall Survival in Men With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer.

Susan Halabi Qian YangAkash RoyBin LuoJohn C AraujoChristopher LogothetisCora N Sternberg Andrew J ArmstrongMichael A CarducciKim N Chi Johann S de Bono Daniel P Petrylak Karim Fizazi Celestia S Higano Michael J MorrisDana E RathkopfFred SaadCharles J RyanEric J Small William Kevin Kelly

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)

This prognostic model for OS in docetaxel-naïve men with mCRPC has been validated using data from seven trials and yields similar results overall and across race, age, and different treatment classes. The prognostic risk groups are robust and can be used to identify groups of patients for enrichment designs and for stratification in randomized clinical trials.

Keyphrases

end stage renal disease
ejection fraction
squamous cell carcinoma
newly diagnosed
locally advanced
middle aged
peritoneal dialysis
small cell lung cancer
machine learning
rectal cancer
artificial intelligence
data analysis
double blind