Prognostic implications of left ventricular diastolic dysfunction in moderate aortic stenosis.
Jan StassenSee Hooi EweSteele C ButcherMohammed R AmanullahBart J MertensKensuke HirasawaGurpreet K SinghKenny Y SinZee Pin DingStephan M PioChing-Hui SiaNicholas W S ChewWilliam KongKian Keong PohDavid CohenPhilippe GénéreuxMartin B LeonNina Ajmone MarsanVictoria DelgadoJeroen J BaxPublished in: Heart (British Cardiac Society) (2022)
LV diastolic dysfunction is independently associated with all-cause mortality and the composite endpoint of all-cause mortality and AVR in patients with moderate AS and preserved LV systolic function. Assessment of LV diastolic function therefore contributes significantly to the risk stratification of patients with moderate AS. Future clinical trials are needed to investigate whether patients with moderate AS and LV diastolic dysfunction may benefit from earlier valve intervention.
Keyphrases
- left ventricular
- aortic stenosis
- ejection fraction
- aortic valve replacement
- mitral valve
- transcatheter aortic valve implantation
- high intensity
- hypertrophic cardiomyopathy
- acute myocardial infarction
- cardiac resynchronization therapy
- heart failure
- clinical trial
- left atrial
- blood pressure
- oxidative stress
- randomized controlled trial
- transcatheter aortic valve replacement
- aortic valve
- current status
- coronary artery disease
- double blind