Compartment-specific multiomic profiling identifies SRC and GNAS as candidate drivers of epithelial-to-mesenchymal transition in ovarian carcinosarcoma.
C. Simon HerringtonAilsa J OswaldLorna J StillieIan CroyMichael ChurchmanRobert L HollisPublished in: British journal of cancer (2023)
CCNE1 gain and chrX loss are frequent in OCS. SRC gain, increased GNAS expression and microRNA dysregulation represent potential mechanisms driving sarcomatous compartment formation.