Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States.
Andrea BilgerEion PlennFrances K BargKatharine A RendleWilliam B CarterAndrea Lamour-HarringtonNora JonesBeth PetersonJohn A SaucedaPablo TebasKaram MounzerDavid MetzgerLuis J MontanerKarine DubePublished in: HIV research & clinical practice (2023)
Managing expectations, focusing on participants' contributions, and providing support to reduce feelings of having failed the research team and/or the HIV community following viral rebound should be part of HIV cure trial design. Discussing the mental health impact of rebound during consent, distinct from risk, is needed. Continued efforts to understand how people with HIV experience ATIs will improve future designs of HIV cure clinical trials.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- mental health
- hepatitis c virus
- hiv aids
- clinical trial
- men who have sex with men
- study protocol
- south africa
- healthcare
- randomized controlled trial
- acute lymphoblastic leukemia
- palliative care
- sars cov
- quality improvement
- current status
- mental illness
- combination therapy