Association between Brain White Matter Lesions and Disease Activity in HAM/TSP Patients.
Keiko TamakiShinji OumaNobutaka TakahashiShinsuke FujiokaYoshio TsuboiPublished in: Neurology international (2024)
Human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients may have brain white matter (WM) lesions, but the association of these lesions with disease activity is poorly understood. We retrospectively evaluated the brain WM lesions of 22 HAM/TSP patients (male 4: female 18) including 5 rapid progressors, 16 slow progressors, and 1 very slow progressor. The severity of WM brain lesions on axial Fluid Attenuated Inversion Recovery images was evaluated utilizing the Fazekas scale, cerebrospinal fluid biomarkers, and proviral load in peripheral blood mononuclear cells. Imaging and biological data were compared at the first visit and a subsequent visit more than 4 years later. Patients with comorbidities including adult T-cell leukemia-lymphoma and cerebrovascular disease were excluded. The results revealed that brain WM lesions in the rapid progressors group were more pronounced than those in slow progressors. In patients with HAM/TSP, severe and persistent inflammation of the spinal cord may cause brain WM lesions.
Keyphrases
- white matter
- disease activity
- end stage renal disease
- spinal cord
- rheumatoid arthritis
- systemic lupus erythematosus
- newly diagnosed
- ejection fraction
- resting state
- cerebrospinal fluid
- multiple sclerosis
- peritoneal dialysis
- magnetic resonance imaging
- prognostic factors
- endothelial cells
- machine learning
- computed tomography
- deep learning
- magnetic resonance
- bone marrow
- mass spectrometry
- juvenile idiopathic arthritis
- patient reported outcomes
- diffuse large b cell lymphoma
- climate change
- neuropathic pain
- brain injury
- photodynamic therapy
- optical coherence tomography
- artificial intelligence
- patient reported
- sensitive detection
- cerebral palsy
- pluripotent stem cells