Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation-deficient mice.
Masayuki ItohHiroyuki OkunoDaisuke YamadaMariko YamashitaManabu AbeRie NatsumeToshie KaizukaKenji SakimuraMikio HoshinoMasayoshi MishinaKeiji WadaMasayuki SekiguchiTakashi HayashiPublished in: Neuropsychopharmacology reports (2018)
Our findings conclude that an appropriate regulation of Arc expression in the dentate gyrus, ensured by AMPA receptor palmitoylation, may be critical for stabilizing hippocampal neural circuits and may suppress excess excitation.