Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes.

Dan Zhao Zeng-Kang Huang Yu Liang Zhi-Jun Li Xue-Wei ZhangKun-Hang LiHao Wu Xu-Dong Zhang Chen-Sheng Li Dong An Xue Sun Ming-Xin An Jun-Xiu Shi Yi-Jun Bao Li Tian Di-Fei WangAn-Hua WuYu-Hua Chen Wei-Dong Zhao

Published in: Circulation research (2024)

These findings uncover the novel role of circulatory pro-CTSD from monocytes in the pathogenesis of cerebral microvascular lesions in diabetes. The circulatory pro-CTSD is a potential target for the intervention of microvascular complications in diabetes.

Keyphrases

type diabetes
cardiovascular disease
glycemic control
anti inflammatory
randomized controlled trial
dendritic cells
extracorporeal membrane oxygenation
blood brain barrier
peripheral blood
risk factors
resting state
risk assessment
insulin resistance
brain injury
weight loss