Testicular cancer is a rare but curable male malignancy. Seminoma represents the majority of germ cell tumors and is considered radiation sensitive. Radiation treatment plays a role in adjuvant therapy after orchiectomy of stage I, IIA, and IIB seminomas. Radiation dose de-escalation has been effective in preventing tumor recurrences while also limiting acute and long-term toxicities. However, long-term risks, including the prevailing concern of secondary malignancy risk, between adjuvant radiation and chemotherapy play a role in recommendations. Ongoing work continues to be performed to reduce radiation field and dose in combination with chemotherapy while still maintaining excellent outcomes.
Keyphrases
- germ cell
- radiation therapy
- papillary thyroid
- radiation induced
- locally advanced
- early stage
- squamous cell carcinoma
- childhood cancer
- metabolic syndrome
- randomized controlled trial
- young adults
- respiratory failure
- clinical practice
- hepatitis b virus
- adipose tissue
- smoking cessation
- weight loss
- acute respiratory distress syndrome