Two intestinal microbiota-derived metabolites, deoxycholic acid and butyrate, synergize to enhance host defense peptide synthesis and alleviate necrotic enteritis.
Dohyung M KimJing LiuMelanie A WhitmoreIsabel TobinZijun ZhaoGuolong ZhangPublished in: Journal of animal science and biotechnology (2024)
DCA synergizes with NaB to induce HDP and claudin-1 expression and enhance NE resistance, with potential for further development as cost-effective antibiotic alternatives.