Purpose in life is associated with less perceived stress and more positive worldviews. This study examined whether people with more purpose adopt a mindset that views stress as beneficial rather than harmful and whether this mindset is one mechanism between purpose and less stress. We used a short-term longitudinal study ( N =2,147) to test stress mindset as a mediator between purpose in life measured prior to the pandemic and stress measured early in the pandemic. We also tested Covid-related worry as a mechanism, given the measurement period spanned pre-pandemic to the first shutdowns in the United States. In contrast to expectations, purpose was unrelated to whether stress was conceptualized as beneficial or harmful (b=.00, SE=.02; p =.710) and thus stress mindset did not mediate the prospective association between purpose and stress. Both purpose in life (b=-.41, SE=.04, p <.001) and stress mindset (b=-.24, SE=.04; p <.001) were independent prospective predictors of stress. Purpose was related to less Covid-related worry, which was a significant mechanism between purpose and stress (indirect effect=-.03, SE=.01; p =.023). A stress-is-enhancing mindset predicted less stress but did not explain why purpose was associated with less perceived stress, whereas fewer Covid-related worries was one pathway from purpose to less stress.