Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness.

Guodong YaoShan YuFeng HouZunyu XiaoGuangqi LiXiaobin JiJi-Gang Wang

Published in: Molecular medicine (Cambridge, Mass.) (2024)

LKB1 deficiency promotes Rab3B upregulation via a CREB-dependent manner. Rab3B interacts with and stabilizes DDX6 protein to accelerate lung adenocarcinoma progression. The Rab3B-DDX6 axis may be potential therapeutic target for lung adenocarcinoma.

Keyphrases

poor prognosis
signaling pathway
risk assessment
small molecule
protein protein
human health