Cardiovascular and mortality events in type 2 diabetes cardiovascular outcomes trials: a systematic review with trend analysis.
Lorenzo M VetroneFrancesco ZaccardiDavid R WebbSam SeiduNitin N GholapDario PitoccoMelanie J DaviesKamlesh KhuntiPublished in: Acta diabetologica (2018)
In contrast to real-world data, there was no evidence of an improvement in all-cause and cardiovascular mortality in type 2 diabetes participants included in control arms of randomised clinical trials across 5 decades. Further studies should investigate whether and how dissimilarities in populations, procedures, and assessments of exposures and outcomes explain the differences between real-world setting and clinical trials.
Keyphrases
- clinical trial
- type diabetes
- glycemic control
- cardiovascular events
- open label
- phase ii
- cardiovascular disease
- risk factors
- double blind
- study protocol
- insulin resistance
- magnetic resonance
- air pollution
- phase iii
- electronic health record
- metabolic syndrome
- machine learning
- randomized controlled trial
- coronary artery disease
- skeletal muscle
- artificial intelligence
- computed tomography
- adipose tissue