Building External Control Arms From Patient-Level Electronic Health Record Data to Replicate the Randomized IMblaze370 Control Arm in Metastatic Colorectal Cancer.

Carsten SchröderMarcus LawranceChen LiChristelle LenainShivani K MhatreMarwan FakihIrmarie Reyes-RiveraMichael T Bretscher

Published in: JCO clinical cancer informatics (2021)

EC arms constructed from the FH database and the CGDB closely replicated the control arm from IMblaze370. EHR-derived EC arms can provide meaningful comparators in mCRC trials when recruiting a randomized control arm is not feasible.

Keyphrases

electronic health record
metastatic colorectal cancer
adverse drug
clinical decision support
randomized controlled trial
open label
clinical trial
phase ii
phase iii