Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice.

Beom Jin LimJoung Il LeeHyun Woong LeeKwan Sik LeeJa Kyung KimHye Young ChangJung Il Lee

Published in: Cell communication and signaling : CCS (2018)

Deletion of PDGFRα in hepatocytes attenuated the upregulation of PDGFRα in HSCs after TAA treatment, resulting in decreased liver fibrosis and HSC activation. This suggests that in the event of chronic liver injury, PDGFRα in hepatocytes plays an important role in liver fibrosis by affecting PDGFRα expression in HSCs.

Keyphrases

liver fibrosis
liver injury
drug induced
growth factor
poor prognosis
cell proliferation
binding protein
signaling pathway