Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: A RANO review.
Lakshmi NayakChetan BettegowdaFlorian SchererNorbert GalldiksManmeet AhluwaliaAlexander BaraniskinLouisa von BaumgartenJacoline E C BrombergAndrés J M FerreriChristian GrommesKhê Hoang-XuanJulia KühnJames L RubensteinRoberta RudàMichael WellerSusan M ChangMartin J Van Den BentPatrick Yung WenRiccardo SoffiettiPublished in: Neuro-oncology (2024)
Thus far, no clinically validated circulating biomarkers for managing both primary and secondary CNS lymphomas exist. There is need of standardization of biofluid collection, choice of analytes, and type of technique to perform the molecular analysis. The various assays should be evaluated through well-organized central testing within clinical trials.