For whom the B(c)ell tolls: CXCL4 AIDs human autoimmunity.
Stuart G TangyePublished in: The Journal of experimental medicine (2023)
In this issue of JEM, Çakan et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230944) explore a CXCL4-mediated mechanism by which TLRs cause autoimmunity in human B cells, breaching bone marrow tolerance.