Endomysial fibrosis, rather than overall connective tissue content, is the main determinant of conduction disturbances in human atrial fibrillation.
Bart MaesenSander VerheuleStef ZeemeringMark La MeirJan NijsStijn LumeijDennis H LauMathieu GranierHarry Jgm CrijnsJos G MaessenStefan DheinUlrich SchottenPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2022)
Atrial fibrillation complexity is highly variable in patients with pAF, but not significantly higher than in patients with acutely induced AF, while in patients with persistent AF complexity is higher. Among the structural alterations studied, endomysial fibrosis, but not overall fibrosis, is the strongest determinant of AF complexity.
Keyphrases
- atrial fibrillation
- oral anticoagulants
- catheter ablation
- left atrial
- left atrial appendage
- direct oral anticoagulants
- endothelial cells
- heart failure
- percutaneous coronary intervention
- high glucose
- liver fibrosis
- diabetic rats
- oxidative stress
- coronary artery disease
- induced pluripotent stem cells
- pluripotent stem cells