Underlying biochemical effects of intermittent fasting, exercise and honey on streptozotocin-induced liver damage in rats.
Ejime Agbonifo-ChijiokwuKingsley E NwangwaMega O OyovwiBenneth Ben-AzuAlexander O NaihoVictor EmojevweEjiro Peggy OhwinAzuka Prosper EhiwariorEvelyn Tarela OjugbeliShalom Udoka NwabuokuEmuesiri Goodies MokeBright O OghenetegaPublished in: Journal of diabetes and metabolic disorders (2023)
IF and exercise greatly decreased liver transcription factor (resistin, SREBP-1c), inflammatory cytokines/enzyme (TNF-α, IL-6, IL-1ß, MPO) as well as oxidative and nitrergic stress with correspondence increased liver PPAR-γ, IL-10, SOD, CAT and GSH in diabetic rats unlike starvation and honey regimen relative to diabetic controls. Furthermore, IF and exercise significantly improved hepatic glycogen synthase and decreased glycogen phosphorylase in diabetic rats compared to the diabetic control group, but starvation and honey therapy had no such influence. IF and exercise strategically reduces STZ-induced liver metabolic disorder via through modulation of liver transcriptional factors and inhibition of pro-inflammatory cytokines, oxido-nitrergic and adipokine signaling pathway.
Keyphrases
- diabetic rats
- oxidative stress
- high intensity
- transcription factor
- signaling pathway
- physical activity
- type diabetes
- rheumatoid arthritis
- insulin resistance
- induced apoptosis
- gene expression
- blood pressure
- epithelial mesenchymal transition
- stem cells
- metabolic syndrome
- adipose tissue
- heat shock
- pi k akt
- fatty acid
- endoplasmic reticulum stress
- mesenchymal stem cells
- blood glucose
- smoking cessation