Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models.
Qian MaQiuhua YangJiean XuHunter G SellersZach L BrownZhiping LiuZsuzsanna BordanXiaofan ShiDingwei ZhaoYongfeng CaiVidhi PareekChunxiang ZhangGuangyu WuZheng DongAlexander D VerinLin GanQuansheng DuStephen J BenkovicJianping WengJohn M AsaraIssam Ben-SahraScott BarmanYunchao SuDavid J R FultonYuqing HuoPublished in: European heart journal (2023)
Targeting ATIC-mediated DNPS compromises the availability of purine nucleotides for incorporation into DNA/RNA, reducing PASMC proliferation and pulmonary vascular remodelling and ameliorating the development and progression of PH.