Therapeutic Potential of RTA 404 in Human Brain Malignant Glioma Cell Lines via Cell Cycle Arrest via p21/AKT Signaling.

Tai-Hsin TsaiAnn-Shung LieuYi-Wen WangSheau-Fang YangYi-Chiang Hsu Chih-Lung Lin

Published in: BioMed research international (2021)

RTA404 can inhibit proliferation, cell locomotion, cell cycle progression, and induce apoptosis in GBM cells in vitro, possibly through its inhibition of N-cadherin and E-cadherin expression via its inhibition of the AKT pathway.

Keyphrases

cell cycle arrest
cell cycle
pi k akt
cell proliferation
signaling pathway
cell death
induced apoptosis
poor prognosis
single cell
cell therapy
binding protein