Adiposity may predict survival in patients with advanced stage cancer treated with immunotherapy in phase 1 clinical trials.
Dylan J MartiniMeredith R KlineYuan LiuJulie M ShabtoMilton A WilliamsAmir Ishaq KhanColleen LewisHannah CollinsMehmet AkceHaydn T KissickBradley C CarthonWalid L ShaibOlatunji B AleseRathi N PillaiConor E SteuerChristina S WuDavid H LawsonRagini R KudchadkarBassel F El-RayesSuresh R RamalingamTaofeek K OwonikokoRobert Donald HarveyViraj A MasterMehmet Asim BilenPublished in: Cancer (2019)
Increased BMI, increased SFI, and decreased IFI may be associated with prolonged survival in patients with cancer who are treated with immunotherapy. Further studies are needed to elucidate the effect of adiposity on the host immune response to immunotherapy.