Recent Advances in Cell-Based Therapies for Ischemic Stroke.
Satoshi SudaChikako NitoShoji YokoboriYuki SakamotoMasataka NakajimaKota SowaHirofumi ObinataKazuma SasakiSean I SavitzKazumi KimuraPublished in: International journal of molecular sciences (2020)
Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including bone marrow mononuclear cells, bone marrow mesenchymal stem cells, dental pulp stem cells, neural stem cells, inducible pluripotent stem cells, and genetically modified stem cells have been found to improve neurological outcomes in animal models of stroke, and there are some ongoing clinical trials assessing their efficacy in humans. In this review, we aim to summarize the recent advances in cell-based therapies to treat stroke.
Keyphrases
- stem cells
- atrial fibrillation
- cell therapy
- induced apoptosis
- cardiovascular disease
- bone marrow
- clinical trial
- cerebral ischemia
- cell cycle arrest
- neural stem cells
- multiple sclerosis
- type diabetes
- signaling pathway
- adipose tissue
- metabolic syndrome
- peripheral blood
- pluripotent stem cells
- cell proliferation
- brain injury
- insulin resistance
- high resolution
- risk assessment
- mass spectrometry
- human health
- climate change
- atomic force microscopy
- weight loss
- single molecule
- phase iii