Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission.
Anna StockbauerLeonie BeyerMaria HuberAnnika KreuzerCarla PalleisSabrina KatzdoblerBoris-Stephan RauchmannSilvia MorbelliAndrea ChincariniRose BruffaertsRik VandenbergheMilica G KrambergerMaja TrostValentina GaribottoNicolas NicastroAurélien LathuilièreAfina W LemstraBart N M van BerckelAndrea PilottoAlessandro PadovaniMiguel A Ochoa-FigueroaAnette DavidssonValle CamachoEnrico PeiraMatteo BaucknehtMatteo PardiniGianmario SambucetiDag AarslandFlavio NobiliMattes GrossJonathan VögleinRobert PerneczkyOliver PogarellKatharina BuergerNicolai FranzmeierAdrian DanekJohannes LevinGünter U HöglingerPeter BartensteinPaul CummingAxel RomingerMatthias BrendelPublished in: European journal of nuclear medicine and molecular imaging (2023)
Disease-specific patterns of altered glucose metabolism and altered metabolic networks are present in DLB subjects without significant dopaminergic loss. Metabolic network alterations in FDG-PET can act as a supporting biomarker in the subgroup of DLB patients without significant dopaminergic loss at symptoms onset.