Plasma neurofilament light chain in association to late-life depression in the general population.

Isabel K SchuurmansMohsen GhanbariCharlotte A M CecilM Arfan IkramAnnemarie I Luik

Published in: Psychiatry and clinical neurosciences (2023)

Higher levels of NfL are cross-sectionally associated with more depressive symptoms and a higher risk of incident depressive events longitudinally. The association was stronger for NfL compared to other plasma biomarkers, suggesting a potential role of neuroaxonal damage in developing late-life depression. This article is protected by copyright. All rights reserved.

Keyphrases

depressive symptoms
sleep quality
social support
cardiovascular disease
oxidative stress
bipolar disorder
risk assessment
physical activity
stress induced