Human Mesenchymal Stem Cells-Derived Exosome Mimetic Vesicles Regulation of the MAPK Pathway and ROS Levels Inhibits Glucocorticoid-Induced Apoptosis in Osteoblasts.
Hongxu LuZhaoxia ZhangZhaoying WangJinkui WangTao MiLiming JinXin WuJunyi LuoYimeng LiuJunhong LiuWenquan CaiPeng GuoDawei HePublished in: Stem cells international (2023)
Our study confirmed that hucMSC-EMVs regulates MAPK-signaling pathway and ROS levels to inhibit DEX-induced osteoblast apoptosis.
Keyphrases
- signaling pathway
- induced apoptosis
- oxidative stress
- endoplasmic reticulum stress
- pi k akt
- mesenchymal stem cells
- diabetic rats
- cell death
- dna damage
- cell cycle arrest
- endothelial cells
- epithelial mesenchymal transition
- high glucose
- reactive oxygen species
- umbilical cord
- stem cells
- pluripotent stem cells
- cell proliferation
- cell therapy