Hsa_circ_0057105 modulates a balance of epithelial-mesenchymal transition and ferroptosis vulnerability in renal cell carcinoma.

Junjie CenYanping LiangZihao FengXu ChenJinlong ChenYinghan WangJiangquan ZhuQuanhui XuGuannan ShuWenbin ZhengHui LiangZhu WangQiong DengJiazheng CaoJunghang LuoXiaohan JinYong Huang

Published in: Clinical and translational medicine (2023)

In RCC, hsa_circ_0057105 regulates COL1A1 and VDAC2 expression through its sponge effect on miR-577, acting like a 'double-edged sword'. These findings provide new insight into the relationship between EMT and ferroptosis in RCC and provide potential biomarkers for RCC surveillance and treatment.

Keyphrases

renal cell carcinoma
epithelial mesenchymal transition
cell death
poor prognosis
long non coding rna
transforming growth factor
cell proliferation
signaling pathway
climate change
public health
long noncoding rna