Forkhead box A2-mediated lncRNA SOX2OT up-regulation alleviates oxidative stress and apoptosis of renal tubular epithelial cells by promoting SIRT1 expression in diabetic nephropathy.

Gang YeMan-Li HuLing Xiao

Published in: Nephrology (Carlton, Vic.) (2022)

Foxa2-mediated SOX2OT up-regulation reduced oxidative stress and apoptosis of RTECs by promoting SIRT1 expression, thus alleviating the progression of DN.

Keyphrases

oxidative stress
transcription factor
diabetic nephropathy
poor prognosis
ischemia reperfusion injury
diabetic rats
dna damage
binding protein
induced apoptosis
stem cells
long non coding rna
endoplasmic reticulum stress
cell cycle arrest
cell death
heat shock
long noncoding rna