dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer.

Qiangsheng HuYi QinJinfeng XiangWensheng LiuWenyan XuQiqing SunShunrong JiJiang LiuZheng ZhangQuanxing NiJin XuXian-Jun YuBo Zhang

Published in: Cell proliferation (2018)

Decreased dCK expression promotes NRF2-driven antioxidant transcription, which further enhances gemcitabine treatment resistance, forming a feedback loop.

Keyphrases

oxidative stress
poor prognosis
transcription factor
dna damage
cell death
anti inflammatory
binding protein
squamous cell carcinoma
radiation therapy
rectal cancer