Effects of Shugan Hewei Granule on Depressive Behavior and Protein Expression Related to Visceral Sensitivity in a Rat Model of Nonerosive Reflux Disease.

Yi WangGuanwu LiXiaosu WangSheng-Liang Zhu

Published in: Evidence-based complementary and alternative medicine : eCAM (2019)

This study provided an evidence that SGHW formula was inferior to Rabeprazole in acid inhibition, but it might reduce the expression of CRF protein of hypothalamus and ACC, lower the levels of NMDAR1 in spinal dorsal horn and SP in esophageal mucosa in lower third of esophagus, and regulate depressive behavior simultaneously, related to the improvement of visceral hypersensitivity in rat model of NERD.

Keyphrases

spinal cord
neuropathic pain
bipolar disorder
insulin resistance
poor prognosis
stress induced
binding protein
drug induced
type diabetes
metabolic syndrome
gastroesophageal reflux disease