An extract of phase II and III trials on recent developments in managing neuropathic pain syndromes: diabetic peripheral neuropathy, trigeminal neuralgia, and postherpetic neuralgia.
William C UpshawLenise G SoileauNicholas R StoreyKassady A PerkinsonPatrick M LutherNoah J SpillersChristopher L RobinsonBenjamin C MillerShahab AhmadzadehOmar ViswanathSahar ShekoohiAlan D KayePublished in: Expert opinion on emerging drugs (2024)
All the mentioned targets for treatments of NP seem to be promising alternatives for existing treatments that often possess poor side effect profiles for patients. However, gene therapy potentially offers the unique ability to inject a plasmid containing growth factors leading to nerve growth and repair. Because of this, gene therapy appears to be the most intriguing new treatment for NP.
Keyphrases
- gene therapy
- neuropathic pain
- phase ii
- spinal cord
- end stage renal disease
- spinal cord injury
- clinical trial
- ejection fraction
- newly diagnosed
- escherichia coli
- open label
- type diabetes
- chronic kidney disease
- peritoneal dialysis
- oxidative stress
- prognostic factors
- randomized controlled trial
- crispr cas
- patient reported outcomes
- wound healing
- peripheral nerve
- double blind
- replacement therapy