CTCF loss mediates unique DNA hypermethylation landscapes in human cancers.
Nathan A DamaschkeJoseph GawdzikMele AvillaBing YangJohn SvarenAvtar RoopraJian-Hua LuoYan P YuSunduz KelesDavid F JarrardPublished in: Clinical epigenetics (2020)
These findings establish CTCF loss as a major mediator in directing localized DNA hypermethylation events in a tissue-specific fashion and further support its role as a driver of the cancer phenotype.