Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021.
Nathaniel M LewisEric A NaiotiWesley H SelfAdit A GindeDavid J DouinH Keipp TalbotJonathan D CaseyNicholas M MohrAnne ZepeskiManjusha GaglaniShekhar A GhamandeTresa A McNealNathan I ShapiroKevin W GibbsD Clark FilesDavid N HagerArber ShehuMatthew E PrekkerHeidi L EricksonMichelle N GongAmira MohamedDaniel J HenningJay S SteingrubIthan D PeltanSamuel M BrownEmily T MartinKinsley HubelCatherine L HoughLaurence W BusseCaitlin C Ten LohuisAbhijit DuggalJennifer G WilsonAlexandra J GordonNida QadirSteven Y ChangChristopher MallowCarolina RivasHilary M BabcockJennie H KwonMatthew C ExlineNatasha HalasaJames D ChappellAdam S LauringCarlos G GrijalvaTodd W RiceJillian P RhoadsWilliam B StubblefieldAdrienne BaughmanKelsey N WomackChristopher J LindsellKimberly W HartYuwei ZhuStephanie J SchragMiwako KobayashiJennifer R VeraniManish M PatelMark W Tenfordenull nullPublished in: The Journal of infectious diseases (2022)
Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P > .05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.