p53 immunohistochemical analysis of fusion-positive uterine sarcomas.
Nissreen MohammadColin J R StewartSarah ChiangGulisa TurashviliBrendan C DicksonTony L NgMartin KoebelW Glenn McCluggageSabrina CroceCheng-Han LeePublished in: Histopathology (2021)
p53 immunohistochemistry may be considered in the initial work-up of a uterine sarcoma, as mutation-type staining would make a fusion-positive sarcoma very unlikely. Mutation-type p53 expression, however, can be seen in a small subset of NTRK1/3-positive sarcomas showing pleomorphic round/ovoid cell histology, which may represent a mechanism of progression in these tumours.