Natural Products and Obesity: A Focus on the Regulation of Mitotic Clonal Expansion during Adipogenesis.
Eugene ChangChoon Young KimPublished in: Molecules (Basel, Switzerland) (2019)
Obesity is recognized as a worldwide health crisis. Obesity and its associated health complications such as diabetes, dyslipidemia, hypertension, and cardiovascular diseases impose a big social and economic burden. In an effort to identify safe, efficient, and long-term effective methods to treat obesity, various natural products with potential for inhibiting adipogenesis were revealed. This review aimed to discuss the molecular mechanisms underlying adipogenesis and the inhibitory effects of various phytochemicals, including those from natural sources, on the early stage of adipogenesis. We discuss key steps (proliferation and cell cycle) and their regulators (cell-cycle regulator, transcription factors, and intracellular signaling pathways) at the early stage of adipocyte differentiation as the mechanisms responsible for obesity.
Keyphrases
- cell cycle
- high fat diet induced
- insulin resistance
- early stage
- type diabetes
- metabolic syndrome
- weight loss
- cell proliferation
- healthcare
- cardiovascular disease
- signaling pathway
- public health
- transcription factor
- mental health
- adipose tissue
- blood pressure
- radiation therapy
- glycemic control
- physical activity
- single molecule
- machine learning
- drinking water
- social media
- big data
- sentinel lymph node
- risk factors
- epithelial mesenchymal transition
- coronary artery disease
- fatty acid
- single cell
- lymph node
- endoplasmic reticulum stress