Effect of hydroalcoholic seed extract of Nigella sativa on hepatic and pancreatic factors of Nrf2 and FGF21 in the regulation of insulin transcription factors of MafA and PDX-1 in streptozotocin-treated diabetic rats.

Mahsa Soleimani-DodranReza Alipanah-MoghadamFarhad JeddiMohammad BabaeiRamin SalimnejadElham Bahreini

Published in: Nutrition & metabolism (2022)

This study showed the therapeutic effects of HENS on diabetic pancreas by reducing oxidative stress and tissue damage, modifying the expression levels of PDX-1 and MafA genes, and regulating insulin secretion and blood glucose levels.

Keyphrases

diabetic rats
oxidative stress
blood glucose
glycemic control
type diabetes
dna damage
ischemia reperfusion injury
transcription factor
induced apoptosis
poor prognosis
genome wide
gene expression
dna methylation
heat shock
long non coding rna
adipose tissue
newly diagnosed
signaling pathway