Novel Treatments for Obesity: Implications for Cancer Prevention and Treatment.
Carla Micaela CutticaIrene Maria BriataAndrea DecensiPublished in: Nutrients (2023)
It is now established that obesity is related to a higher incidence of cancer during a lifespan. The effective treatment of obesity opens up new perspectives in the treatment of a relevant modifiable cancer risk factor. The present narrative review summarizes the correlations between weight loss in obesity and cancer. The current knowledge between obesity treatment and cancer was explored, highlighting the greatest potential for its use in the treatment of cancer in the clinical setting. Evidence for the effects of obesity therapy on proliferation, apoptosis, and response to chemotherapy is summarized. While more studies, including large, long-term clinical trials, are needed to adequately evaluate the relationship and durability between anti-obesity treatment and cancer, collaboration between oncologists and obesity treatment experts is increasingly important.
Keyphrases
- weight loss
- insulin resistance
- papillary thyroid
- metabolic syndrome
- type diabetes
- weight gain
- squamous cell
- bariatric surgery
- high fat diet induced
- randomized controlled trial
- mesenchymal stem cells
- cell death
- risk factors
- body mass index
- endoplasmic reticulum stress
- adipose tissue
- combination therapy
- cell proliferation
- signaling pathway
- skeletal muscle
- climate change
- replacement therapy
- cell cycle arrest