Rates of longitudinal change in 18 F-flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer's disease.
Jeffrey S PhillipsFrederick J NitchieFulvio Da ReChristopher A OlmPhilip A CookCorey T McMillanDavid J IrwinJames C GeeJacob G DubroffMurray GrossmanIlya M Nasrallahnull nullPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)
Results suggested radioligand uptake plateaus or declines in advanced neurodegeneration. Further research should investigate whether results generalize to other radioligands and whether they relate to changes of the radioligand binding site structure or accessibility.