Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome.
Giovanna NasilliLoukia YiangouChiara PalandriElisabetta CerbaiRichard P DavisArjan C HouwelingSimona CasiniCarol Ann RemmePublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
These findings demonstrate for the first time the therapeutic benefit of mexiletine in a human cardiomyocyte model of SCN5A overlap syndrome.