Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases.
Menglong WangWei PanYao XuJishou ZhangJun WanHong JiangPublished in: Journal of inflammation research (2022)
Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities. Interventions targeting microglia have been shown to improve the prognosis of various neurological diseases. Recently, studies have observed the activation of microglia in different cardiovascular diseases. In addition, different approaches that regulate the activity of microglia have been shown to modulate the incidence and progression of cardiovascular diseases. The change in autonomic nervous system activity after neuroinflammation may be a potential intermediate link between microglia and cardiovascular diseases. Here, in this review, we will discuss recent updates on the regulatory role of microglia in hypertension, myocardial infarction and ischemia/reperfusion injury. We propose that microglia serve as neuroimmune modulators and potential targets for cardiovascular diseases.
Keyphrases
- inflammatory response
- cardiovascular disease
- neuropathic pain
- lipopolysaccharide induced
- lps induced
- heart failure
- randomized controlled trial
- blood pressure
- traumatic brain injury
- type diabetes
- blood brain barrier
- metabolic syndrome
- cardiovascular risk factors
- spinal cord
- left ventricular
- risk factors
- small molecule
- risk assessment
- coronary artery disease
- patient safety
- human health
- climate change
- cerebral ischemia
- combination therapy