Electrochemical Amidation: Benzoyl Hydrazine/Carbazate and Amine as Coupling Partners.
Tipu AlamAmitava RakshitHirendra Nath DharaAngshuman PalaiBhisma K PatelPublished in: Organic letters (2022)
An electrochemical amidation of benzoyl hydrazine/carbazate and primary/secondary amine as coupling partners via concomitant cleavage and formation of C(sp 2 )-N bonds has been achieved. This methodology proceeds under metal-free and exogenous oxidant-free conditions producing N 2 and H 2 as byproducts. Mechanistic studies reveal the in situ generations of both acyl and N -centered radicals from benzoyl hydrazines and amines. The utility of this protocol is demonstrated through a large-scale, and synthesis of bezafibrate, a hyperlipidemic drug.
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