Possible role of the receptor of advanced glycation end products (RAGE) in the clinical course of prostate neoplasia in patients with and without type 2 diabetes mellitus.
Gamze AkkusVolkan İzolFesih OkMehtap EvranMerve IncemanSeyda ErdoganHalil Mahir KaplanMurat SertTamer TetikerPublished in: International journal of clinical practice (2020)
We found higher RAGE expression levels in malignant prostate neoplasia than in BPH. As expected, patients with diabetes had higher scores than control patients. Disease progression and survival parameters were worse in patients with high RAGE levels. RAGE expression may be a useful biomarker for the diagnosis and prognosis of prostate cancer.
Keyphrases
- prostate cancer
- poor prognosis
- benign prostatic hyperplasia
- radical prostatectomy
- end stage renal disease
- high grade
- ejection fraction
- newly diagnosed
- chronic kidney disease
- binding protein
- lower urinary tract symptoms
- long non coding rna
- metabolic syndrome
- skeletal muscle
- weight loss
- free survival
- insulin resistance
- cardiovascular risk factors