BDNF and NGF Expression in Preneoplastic Cervical Disease According to HIV Status.
Angelo SiricoSaverio SimonelliSara PignatielloCaterina FulgioneLaura SarnoFrancesco ChiusoGiuseppe Maria MaruottiMatilde SansoneMaurizio GuidaLuigi InsabatoPublished in: International journal of molecular sciences (2023)
In preneoplastic cervical disease, BDNF expression is higher in HIV-infected women than in non-infected controls, and this is independent of the clinical features of the patients and from the presence of the HPV-HR genotype. BDNF can play a key role as a link between the pathways by which HIV and HPV interact to accelerate cervical cancer progression and invasion. These data can be useful to better understand the role of neurotrophins in the cancerogenesis of cervical cancer and the possible therapeutic strategies to improve disease outcomes.
Keyphrases
- hiv infected
- antiretroviral therapy
- human immunodeficiency virus
- poor prognosis
- hiv positive
- end stage renal disease
- hepatitis c virus
- hiv aids
- high grade
- hiv testing
- chronic kidney disease
- newly diagnosed
- ejection fraction
- machine learning
- type diabetes
- prognostic factors
- pregnant women
- long non coding rna
- patient reported outcomes