Proteogenomic Analysis Reveals Proteins Involved in the First Step of Adipogenesis in Human Adipose-Derived Stem Cells.

Bernardo Bonilauri Amanda C Camillo-Andrade Marlon Dias Mariano Santos Juliana de S da G Fischer Paulo Costa Carvalho Bruno Dallagiovanna

Published in: Stem cells international (2021)

These results demonstrate a specific proteome profile related to adipogenesis at the beginning (24 hours) of the differentiation process in hASC, which advances the understanding of human adipogenesis and obesity. Adipogenic differentiation is finely regulated at the transcriptional, posttranscriptional, and posttranslational levels.

Keyphrases

endothelial cells
high fat diet induced
induced pluripotent stem cells
transcription factor
insulin resistance
type diabetes
pluripotent stem cells
metabolic syndrome
gene expression
weight loss
physical activity