Implication of Capillary Morphogenesis Gene 2 (CMG2) in the Disease Progression and Peritoneal Metastasis of Pancreatic Cancer.
Ziqian FangCarly BunstonYali XuFiona RugeLaijian SuiMing LiuBilal Al-SarirehPaul GriffithsKate MurphyMatthew R PughChun-Yi HaoWen Guo JiangLin YePublished in: Cancers (2024)
Capillary morphogenesis gene 2 (CMG2) mediates cell-matrix interactions to facilitate cell adhesion and migration. CMG2 has been implicated in the disease progression of breast cancer, prostate cancer and gastric cancer. The present study aims to determine the role of CMG2 in the disease progression and peritoneal metastasis of pancreatic cancer. Pancreatic tumour samples were collected from Peking University Cancer Hospital. CMG2 expression was determined using quantitative PCR. After the creation of knockdown and overexpression of CMG2 in pancreatic cancer cells, the effect of CMG2 on several cell functions and adhesion to the peritoneum was examined. Potential pathways regulated by CMG2 were found via proteomics analysis and drug tests. CMG2 was upregulated in pancreatic cancer tissues and associated with a poor prognosis. CMG2 was increased in metastatic lesions and those primary tumours with distant metastases. CMG2 promotes cell-cell, cell-matrix and cell-hyaluronic acid adhesion, which may be mediated by epidermal growth factor receptor (EGFR) and focal adhesion kinase (FAK) pathway activation.
Keyphrases
- poor prognosis
- single cell
- epidermal growth factor receptor
- prostate cancer
- small cell lung cancer
- cell adhesion
- long non coding rna
- mass spectrometry
- gene expression
- cystic fibrosis
- risk assessment
- high resolution
- mesenchymal stem cells
- radical prostatectomy
- papillary thyroid
- climate change
- electronic health record
- drug induced
- protein kinase
- binding protein
- genome wide identification