Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells.
O DomarcoD LötschJ SchreiberC DinhofS Van SchoonhovenM D GarcíaC PeinadorB K KepplerW BergerAlessio TerenziPublished in: Dalton transactions (Cambridge, England : 2003) (2018)
Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.