Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.
Paul FineranEmyr Lloyd-EvansNathan A LackNick PlattLianne C DavisAnthony J MorganDoris HöglingerRaju Venkata V TatituriSimon ClarkIan M WilliamsPatricia TynanNada Al EisaEvgeniya NazarovaAnn WilliamsAntony GalioneDaniel S OryGurdyal S BesraDavid G RussellMichael B BrennerEdith SimFrances Mary PlattPublished in: Wellcome open research (2016)
These findings provide a novel mechanistic explanation for mycobacterial intracellular persistence, and suggest that targeting interactions between the mycobacteria and host cell pathways may provide a novel avenue for development of anti-TB therapies.