Obesity is a growing global health crisis intricately connected to various chronic conditions, including arthritis. This paper explores the intricate web of hormonal changes in the context of obesity and their profound influence on the development and progression of arthritis. Hormones, such as leptin, insulin, cortisol, and estrogen, all altered in obesity, play pivotal roles in inflammation, cartilage degradation, mechanical stress, and pain associated with obesity-related arthritis. Additionally, the mechanical stress placed on weight-bearing joints by excess body weight accelerates joint wear and tear, contributing to arthritis. Genetic factors, shared biomarkers, and pathways further link these conditions. Recognizing these connections is vital for healthcare professionals and individuals facing the challenges of obesity and arthritis, offering insights into strategies for prevention, management, and intervention. This comprehensive understanding of the complex interplay between hormonal changes, obesity, and arthritis sheds light on multifaceted mechanisms underlying this intricate relationship.
Keyphrases
- weight loss
- insulin resistance
- metabolic syndrome
- type diabetes
- rheumatoid arthritis
- weight gain
- high fat diet induced
- body weight
- global health
- adipose tissue
- polycystic ovary syndrome
- public health
- body mass index
- skeletal muscle
- chronic pain
- spinal cord injury
- glycemic control
- spinal cord
- autism spectrum disorder
- pain management
- stress induced