Potential biological therapies for severe preeclampsia: a systematic review and meta-analysis.

Sophia GrimesKira BombayAndrea LanesMark WalkerDaniel J Corsi

Published in: BMC pregnancy and childbirth (2019)

The findings of this review are strengthened by rigorous systematic search and review of the literature. Results of our meta-analyses do not currently warrant further exploration of AT as a treatment of preeclampsia in human trials. Results of animal and ex-vivo studies of A1M and MSCs were encouraging and supportive of initiating human investigations.

Keyphrases

endothelial cells
early onset
meta analyses
induced pluripotent stem cells
systematic review
randomized controlled trial
mesenchymal stem cells
risk assessment
pregnancy outcomes
bone marrow
combination therapy
replacement therapy
drug induced