Association of Body Mass Index and Parkinson Disease: A Bidirectional Mendelian Randomization Study.
Cloé DomenighettiPierre-Emmanuel SugierAshwin Ashok Kumar SreelathaClaudia SchulteSandeep GroverBerta PortugalPei-Chen LeePatrick MayDheeraj BobbiliMilena Radivojkov BlagojevicPeter LichtnerAndrew B SingletonDena HernandezConnor EdsallGeorge D MellickAlexander A ZimprichWalter PirkerEkaterina A RogaevaAnthony E LangSulev KõksPille TabaSuzanne LesageAlexis BriceJean-Christophe CorvolMarie-Christine Chartier-HarlinEugenie MutezKathrin BrockmanAngela B DeutschländerGeorgios M HadjigeorgiouEfthimios DardiotisLeonidas StefanisAthina Maria SimitsiEnza Maria ValenteSimona PetrucciLetizia StranieroAnna L ZecchinelliGianni PezzoliLaura BrighinaCarlo FerrareseGrazia AnnesiAndrea QuattroneMonica GagliardiHirotaka MatsuoAkiyoshi NakayamaNobutaka HattoriKenya NishiokaSun Ju ChungYoon Joong KimPierre KolberBart P C Van De WarrenburgBastiaan R BloemMathias ToftLasse PihlstromLeonor Correia GuedesJoaquim José FerreiraSoraya BardienJonathan A CarrEduardo TolosaMario EzquerraPau PastorMónica Diez-FairenKarin WirdefeldtNancy L PedersenCaroline RanAndrea Carmine BelinAndreas PuschmannClara HellbergCarl E ClarkeKaren E MorrisonManuela M X TanDimitri KraincLena F BurbullaMatthew J FarrerRejko KrügerThomas GasserManu SharmaAlexis Elbaznull nullPublished in: Neurology (2024)
Using an independent data set (Courage-PD), we replicate an inverse association of genetically predicted BMI with PD, not explained by survival or incidence-prevalence biases. Moreover, reverse MR analyses support an inverse association between genetic liability toward PD and BMI, in favor of a bidirectional relation.